Cathodic Stripping Voltammetric Determination of Febuxostat in Pharmaceutical Dosage Form and Plasma Samples

Febuxostat FEB was determined by differential pulse “DP” adsorptive stripping voltammetry and hanging mercury drop electrode. In 0.04 mol L Britton-Robinson buffer solution, pH 10, an irreversible electrochemical reaction took place at about -350 mV, and the peak current was linearly varied over the concentration range of 12.5-200 ng mL FEB, with correlation coefficients of 0.9995, after 60 s accumulation time, stirring at a speed of 600 rpm, rest for 10 s, then cathodic stripping sweep from -100 to 600 mV, with a scan rate of 60 mV/s. The limits of detection and quantization were 6.93, 23.09 ng mL. The method was applicable for determining FEB in pharmaceutical tablets and in spiked plasma. The results of the proposed method were compared with that obtained by the UV-spectrophotometric technique.